Automated Synthesizer
In the rapidly evolving field of synthetic chemistry, automation is transforming how chemists approach the synthesis of novel molecules. The integration of SYNTHIA™ Retrosynthesis Software with Synple's Automated Synthesizer offers a groundbreaking solution that streamlines the synthesis process, significantly reducing time and effort while enhancing precision and efficiency.
The Power of Automation in Synthesis
SYNTHIA™ Retrosynthesis Software is a powerful tool that employs expert-coded rules to predict feasible synthetic routes from commercially available starting materials. This software accelerates the route design process by providing chemists with a customized set of ranked potential pathways for any given target molecule. When combined with Synple's automated cartridge-based synthesis technology, SYNTHIA™ facilitates the execution of chemical reactions with minimal manual intervention. This synergy not only saves time but also reduces the potential for human error, making the synthesis process more efficient and reliable.
Case Studies: Efficiency in Action
Two notable case studies highlight the effectiveness of combining SYNTHIA™ and
Synple technologies:
1. Synthesis of Compound C6
This fluoroproline-based compound was synthesized using both traditional and automated methods. The SYNTHIA™ software suggested a two-step route involving alkylation and amide coupling. Using Synple's automated system, the synthesis was completed with only 30 minutes of manual labor, compared to 7.25 hours required for the traditional method. This automation resulted in a 93% reduction in manual time, demonstrating the significant efficiency gains achievable with this technology.
2. Synthesis of Compound C2
A more complex scaffold, this compound was synthesized using both SYNTHIA™ and Synple. The automated route required only 5.5 hours of manual work, compared to 8 hours for the traditional method, achieving a 61% reduction in working time. This case study underscores the potential of automated synthesis to handle complex chemical pathways efficiently.
Customization and Flexibility
SYNTHIA™ allows users to customize search configurations to prioritize reactions that can be executed using the Synple system. This flexibility enables chemists to tailor the synthesis process to their specific needs, optimizing for cost, time, and material availability. The software's ability to predict routes based on commercially available compounds further streamlines the process, eliminating the need for extensive searches for starting materials.
Customization Options
The integration of SYNTHIA™ Retrosynthesis Software with Synple's Automated Synthesizer represents a significant advancement in synthetic chemistry. By automating routine steps and allowing chemists to focus on more complex tasks, this technology enhances productivity and innovation in drug discovery and chemical synthesis. For further inquiries or to schedule a demonstration, please contact our team.
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