The Workflow

Effortlessly transform your ideas into reality with SYNTHIA® Retrosynthesis Software, featuring customizable search options and extensive resources for efficient chemical synthesis. 

1. Input your Target Molecule

Run Analyses for Known or Unknown Compounds

Draw or paste your target molecule in the editor, or search for a known compound in our database.

  • Define stereochemistry
  • Define bonds to make or preserve through the synthesis

Select Analysis Type

  • Automatic
  • Step-by-Step
  • Similiar molecules
  • Shared Path Library
A GIF detailing how targets are input in SYNTHIA
Cogs Settings Icon

2. Customize Your Analysis

Increase efficiency and reduce risk

Quickly find routes that start with commercially available starting materials or your proprietary inventory compounds.

Define search criteria:

  • Use preset parameters or customize them to your needs
  • Include preferred reactions
  • Exclude unwanted reactions or reagents
  • Define starting materials
  • Set price limit for commercial compounds
  • Integrate in-house inventory
A 15 second GIF of a custom search in SYNTHIA

3. Pathway to Innovation

View up to 50 synthetic pathways and use filters based on:

  • Number of steps
  • Similarity of pathways
  • Cost of starting materials
  • Unwanted or desired reactions or molecules

View results in a single map or as individual reaction schemes, including:

  • Typical reaction conditions
  • Illustrative Publications
  • Protecting group requirements
  • Possible side products

Exclude reactions that are undesirable due to:

  • Specialized equipment or technical needs (ozone, gaseous reagents, moisture-sensitive materials)

  • “Exotic” or complex chemistry

Define your preferred reaction conditions:

  • Reagents, catalysts

Share, save and export results:

  • Download pathways as PDF, RDF, SVG
  • Copy reactions and structures
  • Share analyses with team members
A screenshot of a Synthia results page
A screenshot of a Synthia results page
A network of molecules in the palm of a robotic hand

4. Refine and Design

Turn promising routes into shareable, custom pathway designs.
Use the SYNTHIA® Whiteboard to bring together pathways, reactions, and molecules from any analysis result and arrange them on a flexible canvas.

  • Combine ideas from multiple analyses to build convergent or divergent synthetic routes.
  • Edit structures and reactions with the integrated molecule editor, adding your own intermediates, disconnections, and alternatives.
  • Collaborate in real time by sharing Whiteboards with colleagues, collecting comments, and iterating on route designs together.
  • Export your designs in multiple formats (such as CDXML, RDF, and PNG) for documentation, presentations, or use in other cheminformatics tools.
SYNTHIA whiteboard feature with a chemical reaction pathway highlighted in green.

5. Start Your Synthesis

Access vast Chemical Space with 12M unique building blocks

Purchase starting materials

  • Quickly build a shopping list
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Access vast Chemical Space with 12M Aldrich Market Select unique building blocks

Experience our powerful SYNTHIA® Retrosynthesis Software

FREE INDIVIDUAL TRIAL

Benefits of SYNTHIA® Free Trial

  • Cloud-Based Application
  • 30 Day free of charge for up to 5 target molecules
  • Individual license of SYNTHIA® with the power of SYNTHIA® Enterprise
  • Easy Upgrade to the Enterprise version of SYNTHIA® Retrosynthesis Software

unique ideas

„Synthia was able to to suggest unique ideas that complemented the staff ideas. It was very important that the software designed is rules based on trusted literature references.“

— John Lim (MS), GSK Chemical Development

Aurelie from Synthia

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Quickly go from imagining what’s possible to testing what’s probable with a license that fits your needs.

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