The article from Molga et al. explores the use of computational tools to design synthetic routes that avoid patented methods. By identifying and preserving key molecular motifs, the software can autonomously generate alternative pathways that circumvent existing patents, offering new strategies for synthesizing blockbuster drugs. This approach not only aids in navigating intellectual property challenges but also enhances the flexibility and creativity of synthetic planning.

Synthia^® plays a pivotal role in this process by utilizing its extensive database of expert-coded reaction rules and advanced algorithms. It enables chemists to explore innovative synthetic pathways while respecting intellectual property constraints. By integrating Synthia^® into the synthesis planning process, researchers can efficiently design alternative routes, ensuring compliance with patent laws while optimizing the production of valuable compounds.

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Navigating around Patented Routes by Preserving Specific Motifs along Computer-Planned Retrosynthetic Pathways
Molga, K., Dittwald, P., Grzybowski, B.A. | Chem (2019), 5, 460-473